MERKEL CELL POLYOMAVIRUS-SPECIFIC IMMUNE RESPONSES IN PATIENTS WITH MERKEL CELL CARCINOMA RECEIVING ANTI-PD-1 THERAPY

Abstract Background Merkel cell carcinoma (MCC) is an aggressive skin cancer that frequently responds to anti-PD-1 therapy.MCC is associated with sun exposure and, in 80% of cases, Merkel cell polyomavirus (MCPyV).MCPyV-specific T and B cell responses provide a unique opportunity to study cancer-specific immunity throughout PD-1 blockade therapy.Me

A new dinosaur tracksite was found in the Kirmenjak quarry in Istria.It is located about one kilometre from an already existing tracksite.The footprints are placed on a slightly inclined bedding plane at the base of SCOOP the succession represented by heavily stylolitised limestones of the Kirmenjak informal lithostratigraphic unit.The age of the l